Paid Clinical Trials Springfield

Discover 175 paid clinical trials in Springfield, Missouri. Search by condition or phase to find a research study near you that matches your needs across various therapeutic areas.

Filter

Filter results

Results: 175

A Donanemab (LY3002813) Study in Participants With Preclinical Alzheimer's Disease (TRAILBLAZER-ALZ 3)A Donanemab (LY3002813) Study in Participants With Preclinical Alzheimer's Disease (TRAILBLAZER-ALZ 3)

Recruiting

PHASE3

Sponsor:

Eli Lilly and Company

Location:

Bolivar MO, Overland Park KS, Tulsa OK, Chesterfield MOshow 172 more

Code:

NCT05026866

Conditions

Alzheimer Disease

Eligibility Criteria

Sex: All

Age: 65 - 70+

Healthy Volunteers: Not accepted

Interventions

Donanemab

Placebo

Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

Recruiting

PHASE3

Sponsor:

NRG Oncology

Location:

Springfield MO, Bolivar MO, Branson MO, Joplin MOshow 706 more

Code:

NCT05879926

Conditions

Breast Cancer

Eligibility Criteria

Sex: Female

Age: 18 - 60

Healthy Volunteers: Not accepted

Interventions

Ovarian Function Suppression + Aromatase Inhibitor

Adjuvant Chemotherapy + Ovarian Function Suppression

Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib Compared to Subcutaneous Adalimumab in Adult Participants With Moderate to Severe Rheumatoid ArthritisStudy to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib Compared to Subcutaneous Adalimumab in Adult Participants With Moderate to Severe Rheumatoid Arthritis

Recruiting

PHASE3

Sponsor:

AbbVie

Location:

Springfield MO, Kansas City MO, Jonesboro AR, Oklahoma City OKshow 77 more

Code:

NCT05814627

Conditions

Rheumatoid Arthritis

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Upadacitinib

Adalimumab

Upadacitinib Matching Placebo

Adalimumab Matching Placebo

Comparing Proton Therapy to Photon Radiation Therapy for Esophageal CancerComparing Proton Therapy to Photon Radiation Therapy for Esophageal Cancer

Recruiting

PHASE3

Sponsor:

NRG Oncology

Location:

Springfield MO, Little Rock AR, Saint Peters MO, Creve Coeur MOshow 72 more

Code:

NCT03801876

Conditions

Clinical Stage I Esophageal Adenocarcinoma AJCC v8

Clinical Stage I Esophageal Squamous Cell Carcinoma AJCC v8

Clinical Stage I Gastroesophageal Junction Adenocarcinoma AJCC v8

Clinical Stage II Esophageal Adenocarcinoma AJCC v8

Clinical Stage II Esophageal Squamous Cell Carcinoma AJCC v8

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Carboplatin

Esophagectomy

Intensity-Modulated Radiation Therapy

Paclitaxel

Proton Beam Radiation Therapy

Testing the Use of Steroids and Tyrosine Kinase Inhibitors With Blinatumomab or Chemotherapy for Newly Diagnosed BCR-ABL-Positive Acute Lymphoblastic Leukemia in AdultsTesting the Use of Steroids and Tyrosine Kinase Inhibitors With Blinatumomab or Chemotherapy for Newly Diagnosed BCR-ABL-Positive Acute Lymphoblastic Leukemia in Adults

Recruiting

PHASE3

Sponsor:

National Cancer Institute (NCI)

Location:

Springfield MO, Bolivar MO, Joplin MO, Rolla MOshow 142 more

Code:

NCT04530565

Conditions

B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Interventions

Biospecimen Collection

Blinatumomab

Bone Marrow Aspiration and Biopsy

Cyclophosphamide

Cytarabine

Bupropion to Reduce Cancer Related Fatigue in Cancer SurvivorsBupropion to Reduce Cancer Related Fatigue in Cancer Survivors

Recruiting

PHASE3

Sponsor:

University of Rochester NCORP Research Base

Location:

Springfield MO, Bolivar MO, Branson MO, Joplin MOshow 290 more

Code:

NCT03996265

Conditions

Be Diagnosed With Cancer and Have Completed Systemic Therapy

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Bupropion Hydrochloride Controlled-release

Placebo Administration

Quality-of-Life Assessment

Questionnaire Administration

MFOLFIRINOX Versus MFOLFOX with or Without Nivolumab for the Treatment of Advanced, Unresectable, or Metastatic HER2 Negative Esophageal, Gastroesophageal Junction, and Gastric AdenocarcinomaMFOLFIRINOX Versus MFOLFOX with or Without Nivolumab for the Treatment of Advanced, Unresectable, or Metastatic HER2 Negative Esophageal, Gastroesophageal Junction, and Gastric Adenocarcinoma

Recruiting

PHASE3

Sponsor:

Alliance for Clinical Trials in Oncology

Location:

Springfield MO, Bolivar MO, Branson MO, Joplin MOshow 465 more

Code:

NCT05677490

Conditions

Advanced Esophageal Adenocarcinoma

Advanced Gastric Adenocarcinoma

Advanced Gastroesophageal Junction Adenocarcinoma

Clinical Stage III Esophageal Adenocarcinoma AJCC V8

Clinical Stage III Gastric Cancer AJCC V8

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Fluorouracil

Leucovorin Calcium

Oxaliplatin

Irinotecan

Nivolumab

A Study to Evaluate the Efficacy and Safety of Nanosomal Docetaxel Lipid Suspension in Triple Negative Breast Cancer PatientsA Study to Evaluate the Efficacy and Safety of Nanosomal Docetaxel Lipid Suspension in Triple Negative Breast Cancer Patients

Recruiting

PHASE3

Sponsor:

Jina Pharmaceuticals Inc.

Location:

Springfield MO, Columbus GA, Canton OH

Code:

NCT03671044

Conditions

Triple Negative Breast Cancer

Eligibility Criteria

Sex: Female

Age: 18 - 65

Healthy Volunteers: Not accepted

Interventions

Nanosomal Docetaxel Lipid Suspension (75 mg/m2)

Nanosomal Docetaxel Lipid Suspension (100 mg/m2)

Taxotere® (100 mg/m2)

Collection and Storage of Tissue and Blood Samples From Patients With CancerCollection and Storage of Tissue and Blood Samples From Patients With Cancer

Recruiting

Sponsor:

National Cancer Institute LAO

Location:

Springfield MO, Bolivar MO, Branson MO, Joplin MOshow 94 more

Code:

NCT02474160

Conditions

Hematopoietic and Lymphatic System Neoplasm

Malignant Solid Neoplasm

Metastatic Malignant Solid Neoplasm

Recurrent Malignant Solid Neoplasm

Eligibility Criteria

Sex: All

Age: 2+

Healthy Volunteers: Not accepted

Interventions

Cytology Specimen Collection Procedure

Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary TumorsTesting the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors

Recruiting

PHASE2

Sponsor:

National Cancer Institute (NCI)

Location:

Springfield MO, Bolivar MO, Branson MO, Joplin MOshow 368 more

Code:

NCT03866382

Conditions

Bladder Adenocarcinoma

Bladder Clear Cell Adenocarcinoma

Bladder Mixed Adenocarcinoma

Bladder Neuroendocrine Carcinoma

Bladder Small Cell Neuroendocrine Carcinoma

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Biospecimen Collection

Bone Scan

Cabozantinib S-malate

Computed Tomography

Echocardiography