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Leukemia Clinical Trials

Find clinical trials for Leukemia. Search for oncology clinical trials in different cities and states across the United States.

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Study of Sapacitabine in Acute Myeloid Leukemia (AML) or Myelodysplastic Syndromes (MDS)

Recruiting
PHASE1
PHASE2

Sponsor:

Cyclacel Pharmaceuticals, Inc.

Location:

Chicago, Buffalo, Houston

Code:

NCT01211457

Conditions

Acute Myeloid Leukemia

Myelodysplastic Syndromes

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

sapacitabine and decitabine (Part 1 - completed)

sapacitabine and venetoclax (Part 2 - recruiting)

Pilot Study of Anti-CD19 Chimeric Antigen Receptor T Cells (CAR-T Cells) for the Treatment of Relapsed/Refractory CD19+ Malignancies

Recruiting
PHASE1

Sponsor:

University of Utah

Location:

Salt Lake City

Code:

NCT06227026

Conditions

Acute Lymphoblastic Leukemia

Diffuse Large B Cell Lymphoma

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Anti-CD19 CAR-T cells

Combination Chemotherapy and Nelarabine in Treating Patients With T-cell Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma

Recruiting
PHASE2

Sponsor:

M.D. Anderson Cancer Center

Location:

Houston

Code:

NCT00501826

Conditions

T Acute Lymphoblastic Leukemia

T Lymphoblastic Lymphoma

Eligibility Criteria

Sex: All

Age: 0 - 70+

Healthy Volunteers: Not accepted

Interventions

Cyclophosphamide

Cytarabine

Dexamethasone

Doxorubicin Hydrochloride

Mercaptopurine

Myeloablative Allo HSCT With Related or Unrelated Donor for Heme Disorders

Recruiting
PHASE2

Sponsor:

Masonic Cancer Center, University of Minnesota

Location:

Minneapolis

Code:

NCT03314974

Conditions

Acute Leukemia

Acute Myeloid Leukemia

Acute Lymphoblastic Leukemia

Lymphoma

Chronic Myelogenous Leukemia

Eligibility Criteria

Sex: All

Age: 0 - 60

Healthy Volunteers: Not accepted

Interventions

HSCT with TBI Regimen

HSCT with Non-TBI Regimen

Study of Crenolanib vs Midostaurin Following Induction Chemotherapy and Consolidation Therapy in Newly Diagnosed FLT3 Mutated AML

Recruiting
PHASE3

Sponsor:

Arog Pharmaceuticals, Inc.

Location:

Duarte, Los Angeles, Sacramento, New Havenshow 17 more

Code:

NCT03258931

Conditions

Newly Diagnosed FLT3 Mutated AML

Eligibility Criteria

Sex: All

Age: 18 - 60

Healthy Volunteers: Not accepted

Interventions

Crenolanib

Midostaurin

Cytarabine

Duanorubicin

Venetoclax for the Treatment of Patients With Relapsed Hairy Cell Leukemia

Recruiting
PHASE2

Sponsor:

National Cancer Institute (NCI)

Location:

Aventura, Coral Gables, Coral Springs, Deerfield Beachshow 5 more

Code:

NCT06311227

Conditions

Recurrent Hairy Cell Leukemia

Recurrent Hairy Cell Leukemia Variant

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Biospecimen Collection

Bone Marrow Aspiration

Bone Marrow Biopsy

Computed Tomography

Magnetic Resonance Imaging

Activated T-Cells Expressing 2nd or 3rd Generation CD19-Specific CAR, Advanced B-Cell NHL, ALL, and CLL (SAGAN)

Recruiting
PHASE1

Sponsor:

Baylor College of Medicine

Location:

Houston

Code:

NCT01853631

Conditions

Non-Hodgkin Lymphoma

Chronic Lymphocytic Leukemia

Acute Lymphocytic Leukemia

Eligibility Criteria

Sex: All

Age: 0 - 70+

Healthy Volunteers: Not accepted

Interventions

Dose Escalation Phase:CD19.CAR/28 and CD19.CAR/28137 T cells

Expansion Phase: CD19.CAR/28 and CD19.CAR/28137 T cells

Interferon-γ (IFN-γ) With Donor Leukocyte Infusion to Treat Relapsed Acute Myeloid Leukemia and Myelodysplastic Syndromes Post Allogeneic Hematopoietic Stem Cell Transplantation

Recruiting
PHASE2

Sponsor:

Sawa Ito, MD

Location:

Pittsburgh

Code:

NCT06529731

Conditions

Acute Myeloid Leukemia

Myelodysplastic Syndromes

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Interferon gamma-1b

Donor Leukocyte Infusion (DLI)

A Study of MGD024 in Patients With Relapsed or Refractory Hematologic Malignancies

Recruiting
PHASE1

Sponsor:

MacroGenics

Location:

Denver, Baltimore, Boston, Grand Rapidsshow 3 more

Code:

NCT05362773

Conditions

Leukemia, Acute Myeloid

Myelodysplastic Syndromes

Classical Hodgkin Lymphoma

Leukemia, B-cell

Leukemia, Hairy Cell

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

MGD024

Safety of Myeloablative Conditioning, Orca-T, and Allogeneic, Donor-Derived CD19/CD22-CAR (Chimeric Antigen Receptor) T Cells in Adults With B-cell Acute Lymphoblastic Leukemia (ALL)

Recruiting
PHASE1

Sponsor:

Dr. Melody Smith, MD, MS

Location:

Palo Alto

Code:

NCT05507827

Conditions

Lymphoid Leukemia

Eligibility Criteria

Sex: All

Age: 18 - 65

Healthy Volunteers: Not accepted

Interventions

Allogeneic donor-derived T-cells transduced with bivalent lentiviral vector (CD19/CD22-BBz) chimeric antigen receptor (CAR)

Treg CD34+HSPC (Orca-T)

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