Oncology Clinical Trials
Find clinical trials for oncology. Search for oncology clinical trials in different cities and states across the United States.
Obinutuzumab and Ibrutinib as Front Line Therapy in Treating Patients With Indolent Non-Hodgkin's Lymphomas
Sponsor:
Sidney Kimmel Cancer Center at Thomas Jefferson University
Location:
Code:
NCT03198026
Conditions
Non-Hodgkin's Lymphoma
Ann Arbor Stage II Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue
Ann Arbor Stage II Follicular Lymphoma
Ann Arbor Stage II Nodal Marginal Zone Lymphoma
Ann Abor Stage III B-Cell Non-Hodgkin Lymphoma
Eligibility Criteria
Sex: All
Age: 18+
Healthy Volunteers: Not accepted
Interventions
Ibrutinib
Obinutuzumab
Laboratory Biomarker Analysis
Study of Sapacitabine in Acute Myeloid Leukemia (AML) or Myelodysplastic Syndromes (MDS)
Sponsor:
Cyclacel Pharmaceuticals, Inc.
Location:
Code:
NCT01211457
Conditions
Acute Myeloid Leukemia
Myelodysplastic Syndromes
Eligibility Criteria
Sex: All
Age: 18+
Healthy Volunteers: Not accepted
Interventions
sapacitabine and decitabine (Part 1 - completed)
sapacitabine and venetoclax (Part 2 - recruiting)
A Study of NVL-655 in Patients With Advanced NSCLC and Other Solid Tumors Harboring ALK Rearrangement or Activating ALK Mutation (ALKOVE-1)
Sponsor:
Nuvalent Inc.
Location:
Code:
NCT05384626
Conditions
Locally Advanced Solid Tumor
Metastatic Solid Tumor
Eligibility Criteria
Sex: All
Age: 12+
Healthy Volunteers: Not accepted
Interventions
NVL-655
AOH1996 for the Treatment of Refractory Solid Tumors
Sponsor:
City of Hope Medical Center
Location:
Code:
NCT05227326
Conditions
Refractory Malignant Solid Neoplasm
Osteosarcoma
Leiomyosarcomas
Synovial Sarcomas
Ovarian Cancer
Eligibility Criteria
Sex: All
Age: 18+
Healthy Volunteers: Not accepted
Interventions
PCNA Inhibitor AOH1996
Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer
Sponsor:
Aulos Bioscience, Inc.
Location:
Code:
NCT05267626
Conditions
Advanced Solid Tumor
Metastatic Cancer
Eligibility Criteria
Sex: All
Age: 18+
Healthy Volunteers: Not accepted
Interventions
AU-007
Aldesleukin
Avelumab
Study of Iberdomide, Bortezomib, Dexamethasone With Isatuximab Added on Demand for ND-NTE MM Patients
Sponsor:
Canadian Myeloma Research Group
Location:
Code:
NCT05272826
Conditions
Multiple Myeloma
Eligibility Criteria
Sex: All
Age: 65+
Healthy Volunteers: Not accepted
Interventions
Iberdomide
Bortezomib
Dexamethasone
Isatuximab
Serial Circulating Tumor DNA (ctDNA) Monitoring During Adjuvant Capecitabine in Early Triple-negative Breast Cancer
Sponsor:
Stanford University
Location:
Code:
NCT04768426
Conditions
Triple Negative Breast Cancer
Breast Cancer
Eligibility Criteria
Sex: All
Age: 18+
Healthy Volunteers: Not accepted
Interventions
Capecitabine
Bruton's Tyrosine Kinase (BTK) Inhibitor, Ibrutinib, in Patients With Newly Diagnosed or Refractory/Recurrent Primary Central Nervous System Lymphoma (PCNSL) and Refractory/Recurrent Secondary Central Nervous System Lymphoma (SCNSL)
Sponsor:
Memorial Sloan Kettering Cancer Center
Location:
Code:
NCT02315326
Conditions
Adult Patients With Newly Diagnosed or Relapsed or Refractory Primary Central Nervous System Lymphoma (PCNSL)
Or Relapsed or Refractory Secondary Central Nervous System Lymphoma (SCNSL)
Eligibility Criteria
Sex: All
Age: 18+
Healthy Volunteers: Not accepted
Interventions
Ibrutinib
HD- Methotrexate (MTX)
Rituximab + HD- Methotrexate (MTX)
procarbazine
Phase 1 Study of Ibrutinib and Immuno-Chemotherapy Using Temozolomide, Etoposide, Doxil, Dexamethasone, Ibrutinib,Rituximab (TEDDI-R) in Primary CNS Lymphoma
Sponsor:
National Cancer Institute (NCI)
Location:
Code:
NCT02203526
Conditions
Primary Central Nervous System Lymphoma
Eligibility Criteria
Sex: All
Age: 18+
Healthy Volunteers: Not accepted
Interventions
Isavuconazole
TEDDI
Rituximab
Cytarabine
TEDD
Pilot Study of Anti-CD19 Chimeric Antigen Receptor T Cells (CAR-T Cells) for the Treatment of Relapsed/Refractory CD19+ Malignancies
Sponsor:
University of Utah
Location:
Code:
NCT06227026
Conditions
Acute Lymphoblastic Leukemia
Diffuse Large B Cell Lymphoma
Eligibility Criteria
Sex: All
Age: 18+
Healthy Volunteers: Not accepted
Interventions
Anti-CD19 CAR-T cells
What are clinical trials for cancer?
Clinical trials for cancer are research studies that aim to evaluate new ways to prevent, detect, or treat cancer. These trials test the safety and effectiveness of new treatments, procedures, or drugs in comparison to current standards. They may also show which medical approaches work best for certain types of cancer or groups of people.
The importance of clinical trials in cancer research
Cancer clinical trials are crucial for developing new methods to fight cancer, improving patient outcomes, and may offer participants access to cutting-edge therapies before they are widely available.
Types of cancer clinical trials
Oncology clinical trials are designed to address different aspects of cancer care, including how to treat cancer, prevent it, find it early, or improve the quality of life for people with cancer. The main types are:
Treatment trials
Treatment trials test new treatments or new combinations of treatments, such as new drugs, new surgical techniques, or new radiation therapies. The goal is to find more effective ways to treat cancer with fewer side effects.
Prevention trials
Prevention trials look for better ways to prevent cancer in people who have never had cancer or to prevent cancer from returning. These trials may include studying medicines, vaccines, vitamins, minerals, or lifestyle changes.
Screening trials
Screening trials test the best way to detect cancer, especially in its early stages. These trials study new examinations or tests that might be more effective, safer, or less invasive than the current standard screening methods.
Quality of life trials for cancer survivors
Quality of life trials (or supportive care trials) explore ways to improve comfort and the quality of life for individuals with terminal types of cancer and cancer survivors. They may study issues such as managing side effects of treatment, physical, psychological, and social side effects of cancer and its treatment.
Who can participate in oncology trials?
Eligibility for oncology trials varies widely depending on the study's objectives. Factors can include the type and stage of cancer, previous treatment history, age, gender, overall health, and other medical conditions. Researchers conducting the trial set specific criteria for each trial to ensure accurate and reliable results and to keep participants safe.
What to expect when participating in a cancer clinical trial
Participating in a cancer clinical trial often involves detailed screenings, regular health check-ups, and a structured treatment plan. Participants may receive the new treatment being tested, a standard treatment for their cancer, or a placebo, depending on the trial's design. Throughout the trial, researchers will monitor the health of participants and the effectiveness and side effects of the treatment.
Benefits and risks of participating in cancer clinical trials
Participating in cancer clinical trials offers potential benefits, including access to new treatments before they are widely available and contributing to medical research that may benefit others in the future. They also receive close monitoring from a dedicated healthcare team.
However, there are also risks, such as the new treatments under study are not always better than the standard care, and there may be unexpected side effects. Participation may also require more of their time and attention, including trips to the study site, more treatments, hospital stays, or complex dosage requirements.
Unsure about participating in clinical trials? Dive into our comprehensive guide to learn about the process, benefits, and potential impact of your involvement. Get the facts you need to make an informed decision today!
How to enroll in a clinical trial for cancer
Enrolling in a cancer clinical trial through our platform is a straightforward and user-friendly process. Here's how to get started:
- Identify Your Trial: Use our intuitive search bar or filter options to locate clinical trials specific to your cancer type. This first step simplifies the process of finding relevant research studies tailored to your needs.
- Select Your Preferred Location: To find trials conveniently located near you, simply input your preferred location into the dedicated filter bar on the left-hand side of the page.
- Explore Study Details: For in-depth information about each study, simply click the “Learn More” button. This will provide you with comprehensive details about the trial, including objectives, procedures, and eligibility criteria.
- Complete the Health Profile: After clicking on the “Get started” button you will be taken to our efficient 5-step application process to provide important health information. This helps us match you with the clinical trial that best fits your needs.
- Submit the Application: After completing the application, send it in. A clinical trial coordinator will review it and contact you regarding the possibility of participation.