Discover 2,107 paid clinical trials in Philadelphia, Pennsylvania. Search by condition or phase to find a research study near you that matches your needs across various therapeutic areas.
Sponsor:
Sabine Mueller, MD, PhD
Location:
Code:
NCT05465174
Conditions
Craniopharyngioma, Child
Craniopharyngioma
Recurrent Craniopharyngioma
Eligibility Criteria
Sex: All
Age: 1 - 39
Healthy Volunteers: Not accepted
Interventions
Nivolumab
Tovorafenib
Sponsor:
Rigel Pharmaceuticals
Location:
Code:
NCT06161974
Conditions
High Grade Glioma
Astrocytoma
Astrocytoma, Grade III
Astrocytoma, Grade IV
Diffuse Intrinsic Pontine Glioma
Eligibility Criteria
Sex: All
Age: 12 - 39
Healthy Volunteers: Not accepted
Interventions
Olutasidenib + TMZ
Sponsor:
Janssen Research & Development, LLC
Location:
Code:
NCT06319820
Conditions
Non-Muscle Invasive Bladder Cancer
Eligibility Criteria
Sex: All
Age: 18+
Healthy Volunteers: Not accepted
Interventions
TAR-210
Gemcitabine
MMC
Sponsor:
Lantern Pharma Inc.
Location:
Code:
NCT05933265
Conditions
Advanced Solid Tumor
Metastatic Solid Tumor
GBM
TNBC - Triple-Negative Breast Cancer
NSCLC
Eligibility Criteria
Sex: All
Age: 18+
Healthy Volunteers: Not accepted
Interventions
LP-184
Spironolactone
Olaparib
Sponsor:
Thomas Jefferson University
Location:
Code:
NCT01514565
Conditions
Breast Cancer
Eligibility Criteria
Sex: Female
Age: 18+
Healthy Volunteers: Not accepted
Sponsor:
Incyte Corporation
Location:
Code:
NCT06516965
Conditions
Prurigo Nodularis
Eligibility Criteria
Sex: All
Age: 18 - 70+
Healthy Volunteers: Not accepted
Interventions
Povorcitinib
Placebo
Sponsor:
Thomas Jefferson University
Location:
Code:
NCT06025565
Conditions
Elbow Tendinopathy
Tendinopathy
Tennis Elbow
Eligibility Criteria
Sex: All
Age: 18 - 70+
Healthy Volunteers: Not accepted
Interventions
Pain Experience Measures
Sponsor:
Cytokinetics
Location:
Code:
NCT06736574
Conditions
Heart Failure
Heart Failure with Reduced Ejection Fraction
Eligibility Criteria
Sex: All
Age: 18 - 70+
Healthy Volunteers: Not accepted
Interventions
Omecamtiv Mecarbil (OM)
Placebo
Sponsor:
Biogen
Location:
Code:
NCT05531565
Conditions
Subacute Cutaneous Lupus Erythematosus
Chronic Cutaneous Lupus Erythematosus
Eligibility Criteria
Sex: All
Age: 18+
Healthy Volunteers: Not accepted
Interventions
Litifilimab
Placebo
Sponsor:
The Mary Elizabeth Groff Surgical Medical Research and Education Charitable Trust
Location:
Code:
NCT00094874
Conditions
Interstitial Cystitis
Eligibility Criteria
Sex: All
Age: 18 - 65
Healthy Volunteers: Not accepted
Interventions
Acupuncture
Philadelphia boasts a strong healthcare network and prominent medical research centers, making it a pivotal location for a diverse range of clinical trials. Renowned institutions such as the University of Pennsylvania, Thomas Jefferson University, and Temple University lead the way in innovative research. These centers are known for their cutting-edge studies across various fields, including oncology, cardiology, neurology, and infectious diseases.
The city’s rich tapestry of clinical research is supported by its diverse population, while the collaborative research environment in Philadelphia also fosters groundbreaking discoveries that can transform patient care and improve health outcomes on a broader scale.
Philadelphia offers key advantages for individuals considering participation in clinical trials. The city is home to a diverse population, which enriches the participant pool and enhances the applicability of research findings across different demographics.
By engaging in a clinical trial in Philadelphia, participants not only gain access to pioneering treatments and therapies but also contribute to vital medical research that can lead to significant breakthroughs. The city’s collaborative environment fosters a supportive framework for clinical research, ensuring individuals are well cared for throughout the process while helping to shape the future of healthcare.
Philadelphia is a leading center for clinical research, with several renowned medical institutions conducting trials across a wide range of conditions.
Philadelphia's emphasis on cardiovascular health is reflected in the numerous clinical trials targeting conditions like coronary artery disease, heart failure, and arrhythmias. Major institutions, including Thomas Jefferson University Hospital and Penn Medicine, are at the forefront of research into new medications, surgical techniques, and lifestyle interventions aimed at improving heart health.
Trials may explore innovative treatments such as transcatheter aortic valve replacement (TAVR), which is less invasive than traditional open-heart surgery. Researchers are also examining the effects of lifestyle changes, such as diet and exercise, on heart health, aiming to develop comprehensive strategies for prevention and management.
Philadelphia is recognized for its groundbreaking cancer research, particularly at institutions such as the University of Pennsylvania's Abramson Cancer Center and Thomas Jefferson University. Clinical trials often focus on a variety of cancers, including breast cancer, lung cancer, prostate cancer, and hematologic malignancies like leukemia and lymphoma. Significant advancements in this area include studies on immunotherapies, such as CAR-T cell therapy, which involves modifying a patient’s T-cells to better attack cancer cells.
The rich research landscape for neurological conditions in Philadelphia is bolstered by institutions like the University of Pennsylvania and the Moss Rehabilitation Research Institute. Clinical trials often focus on disorders such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis (MS), and stroke. Investigations in this area frequently involve novel pharmacological treatments aimed at slowing disease progression and enhancing cognitive and motor functions.
Philadelphia has established itself as a vital center for infectious disease research. Clinical trials often target diseases such as HIV/AIDS, hepatitis C, and COVID-19. Researchers are exploring the efficacy of new antiviral therapies, vaccines, and preventive strategies to combat these illnesses. For example, recent studies have focused on long-acting injectable therapies for HIV that aim to improve adherence to treatment regimens.
The city has also played a significant role in COVID-19 vaccine trials, contributing to the rapid development of safe and effective vaccines during the pandemic. These studies aim to evaluate not only vaccine efficacy but also strategies for equitable distribution and access in underserved communities.
Philadelphia is a hub for diabetes research, with clinical trials focusing on both Type 1 and Type 2 diabetes management. Leading institutions like Temple University and Penn Medicine are investigating new insulin formulations, advanced monitoring devices, and lifestyle interventions to enhance glycemic control.
Researchers are exploring the use of continuous glucose monitors (CGMs) and insulin pumps to optimize diabetes management. Trials may also examine the effectiveness of novel drugs that target specific pathways involved in insulin resistance and glucose metabolism. These studies aim to improve patient management and reduce complications associated with diabetes, ultimately leading to better long-term health outcomes.
Mental health research is a growing focus in Philadelphia, with trials targeting conditions such as depression, anxiety, and schizophrenia. Leading institutions are investigating innovative treatment options that can offer new hope for patients.
Recent studies have explored the use of ketamine, a fast-acting antidepressant, and transcranial magnetic stimulation (TMS) for treatment-resistant depression. These therapies aim to provide relief for patients who have not responded to traditional antidepressants. Additionally, researchers are looking into the impact of psychotherapy combined with pharmacological treatments, emphasizing the need for a holistic approach to mental health care.
Philadelphia is also recognized for its research on rare diseases, particularly through specialized centers at institutions like Children's Hospital of Philadelphia (CHOP). Clinical trials in this area often focus on genetic disorders, metabolic diseases, and conditions such as cystic fibrosis.
Researchers are actively investigating novel gene therapies that aim to correct the underlying genetic defects causing these disorders. These studies are crucial for developing new treatment options that can significantly impact the lives of patients suffering from rare diseases, often leading to improved quality of life and increased life expectancy.
In Philadelphia, clinical trials are governed by a combination of federal, state, and local regulations that ensure the ethical conduct of research involving human subjects. At the federal level, the U.S. Food and Drug Administration (FDA) and the Office for Human Research Protections (OHRP) provide overarching guidelines, including the necessity for Institutional Review Board (IRB) approval before any trial can commence. The IRB is responsible for ensuring that the rights and welfare of participants are protected, assessing the risk-benefit ratio of the study, and verifying that informed consent is obtained from all participants.
Pennsylvania also has specific statutes that outline the rights of research participants and the obligations of researchers on a state level. These regulations emphasize the importance of transparency, informed consent, and data protection. Local institutions often have their own additional guidelines and protocols that align with both federal and state regulations while incorporating best practices for clinical research.
Engaging in a clinical trial offers a remarkable opportunity for individuals to experience innovative treatments and therapies prior to their general release. Participants receive customized care, with healthcare professionals diligently monitoring their health and progress throughout the study. This attentive oversight not only aids in managing any side effects but also maximizes the benefits of the experimental treatments.
Taking part in clinical trials is essential for the progression of medical research and innovation, frequently leading to significant breakthroughs that enhance both the treatment and prevention of various health conditions. By participating in these trials, individuals gain early access to potentially transformative therapies while contributing meaningfully to the scientific community’s understanding of disease and treatment methodologies.
Worried about the risks of participating in a clinical trial? Read our comprehensive guide to gain insights into the potential outcomes of participating. Learn about potential risks, benefits, and safety considerations to make an informed decision about your participation in a clinical trial.
Enrolling in a clinical trial through our platform is a straightforward and user-friendly process. Here's how to get started: