Recruiting

Observational Study

Sponsor:

Penn State University

Code:

NCT06828523

Conditions

Amyotrophic Lateral Sclerosis

Eligibility Criteria

Sex: All

Age: 18 - 65

Healthy Volunteers: Accepted

Interventions

Listener judgements of speech produced in different tasks

Study Details

Brief summary:

In this study, we will evaluate how solo, naive listeners perceive the speech of people with amyotrophic lateral sclerosis (ALS) and age-matched speakers produced across interactive and non-interactive contexts with an unfamiliar, naive interlocutor.

Conditions

Amyotrophic Lateral Sclerosis

Study ID

NCT06828523

Start date

Oct 17, 2025

Status verified date

Feb, 2026

Completion date

Feb 28, 2029

Anticipated

Primary completion date

Feb 28, 2029

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 65

Healthy Volunteers: Accepted

Inclusion Criteria:

  • passing the remote hearing screening
  • having no known speech, language or neurological disorders per self-report
  • being a native monolingual speaker of American English
  • having no experience communicating with people with dysarthria
  • being between the ages of 18 and 65.

Exclusion Criteria:

  • None - if volunteer meets the inclusion criteria, then they will be enrolled

Study Design

Enrollment

1300 participants

Anticipated

Intervention Model

Single group

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Listener Perception of Speech Produced in Different Task Settings

Listeners will hear recorded speech of PALS and age-matched speakers produced within interactive and non-interactive contexts and indicate what they heard.

Interventions

Listener judgements of speech produced in different tasks

Listeners will hear recorded speech of PALS and age-matched speakers across interactive and non-interactive tasks and indicate what they heard by clicking one of four words displayed on the screen. Standard attention checks and minimum performance thresholds (Theodore, 2021) will be used to ensure that listeners are engaged and are able to provide meaningful perceptual judgments.

Primary outcome measure

  • Intelligibility of recorded speech [ Time Frame: one 20 minute session ]

Central Contacts and Locations

Central contacts

Anne Olmstead, Ph.D.

814-867-3373ajo150@psu.edu

Locations

Speech Core, Pennsylvania State University

Recruiting

University Park, Pennsylvania, United States, 16802

Contacts

Jimin Lee, Ph.D.

814-867-3373jxl91@psu.edu

More Information

Sponsor

Penn State University

Last update posted

Feb 12, 2026

Last verified

Feb, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-30. This information was provided to ClinicalTrials.gov by Penn State University on 2026-02-12. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.