Recruiting

Virtual Reality

Sponsor:

Mayo Clinic

Code:

NCT06262126

Conditions

Gastrointestinal Diseases

Chest Pain

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

Virtual Reality

Study Details

Brief summary:

The purpose of this study is to determine if virtual reality (VR) will improve symptoms in non-cardiac chest pain (NCCP).

Conditions

Gastrointestinal Diseases

Chest Pain

Study ID

NCT06262126

Start date

Feb 14, 2024

Status verified date

Feb, 2026

Completion date

Dec 31, 2026

Anticipated

Primary completion date

Jul 31, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Symptoms of non-cardiac chest pain (recurrent anginal-like or atypical chest pain)
  • Negative prior cardiac evaluation (at a minimum, including electrocardiogram)
  • Prior esophagogastroduodenoscopy and/or barium esophagram to rule out severe esophagitis, stricture, or motility abnormality

Exclusion Criteria:

  • Initiation of a proton pump inhibitor (PPI) within 8 weeks
  • Major concomitant illness
  • Current drug or alcohol use that that would interfere with adherence to study requirements
  • Symptoms of vertigo or dizziness that would limit tolerability of the VR headset

Study Design

Enrollment

10 participants

Anticipated

Intervention Model

Single group

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

other: VR Arm

Viritual Reality therapy arm. All patients will receive virtual reality therapy.

Interventions

Virtual Reality

Virtual Reality therapy

Primary outcome measure

  • Measure changes in GERD symptoms using the GERDQ questionnare [ Time Frame: Week 2 ]
  • Measure changes in GERD quality of life using the GERD-HRQL questionnaire [ Time Frame: Week 2 ]
  • Measure changes in esophageal symptom specific anxiety using the EHAS questionnaire [ Time Frame: Week 2 ]
  • Measure changes in GI symptom severity using the PAGI-SYM questionnaire [ Time Frame: Week 2 ]
  • Measure changes in GI related patient assessment of quality of life using PAGI-QOL [ Time Frame: Week 2 ]

Central Contacts and Locations

Locations

Mayo Clinic Florida

Recruiting

Jacksonville, Florida, United States, 32224

Contacts

Wendi Lehman

904-953-8742Lehman.Wendi@mayo.edu

More Information

Sponsor

Mayo Clinic

Last update posted

Feb 12, 2026

Last verified

Feb, 2026

Keywords

  • Virtual reality

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-30. This information was provided to ClinicalTrials.gov by Mayo Clinic on 2026-02-12. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.