Clinical Trials In St. Louis

Discover hundreds of clinical trials in St. Louis.
Search clinical trials in St. Louis by condition or phase.

e.g. Respiratory Diseases

St. Louis•Healthy volunteers: No

Filter results

Results: 1,432

A First-in-human Dose Escalation and Expansion Study to Evaluate the Safety, and Tolerability of AZD8421 Alone or in Combination in Participants With Selected Advanced or Metastatic Solid Tumors

Recruiting

Phase 1

Phase 2

Sponsor:

AstraZeneca

Location:

Saint Louis, Providence, Nashville, Houston

Code:

NCT06188520

Conditions

ER+ HER2- Advanced Breast Cancer

High-grade Serous Ovarian Cancer (HGSOC)

Eligibility Criteria

Sex: Female

Age: 18+

Healthy Volunteers: Not accepted

Interventions

AZD8421

Camizestrant

Ribociclib

Palbociclib

Abemaciclib

A Phase 2 Study of Firi-cel in Patients With Relapsed/Refractory Large B-cell Lymphoma

Recruiting

Phase 2

Sponsor:

CARGO Therapeutics

Location:

Saint Louis, Little Rock, Duarte, Los Angelesshow 23 more

Code:

NCT05972720

Conditions

Cancer

Relapsed/Refractory Large B-cell Lymphoma (LBCL)

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Fludarabine (Conditional therapy)

Cyclophosphamide Monohydrate (Conditional therapy)

firi-cel (Experimental drug)

A First-in-Human Study of BGB-C354 Alone and in Combination With Tislelizumab in Participants With Advanced Solid Tumors

Recruiting

Phase 1

Sponsor:

BeiGene

Location:

Saint Louis, Orlando, Houston, San Antonio

Code:

NCT06422520

Conditions

Advanced Solid Tumor

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

BGB-C354

Tislelizumab

Open-Label Umbrella Study To Evaluate Safety And Efficacy Of Elacestrant In Various Combination In Patients With Metastatic Breast Cancer

Recruiting

Phase 1

Phase 2

Sponsor:

Stemline Therapeutics, Inc.

Location:

Saint Louis, Dothan, Phoenix, Springdaleshow 37 more

Code:

NCT05563220

Conditions

Breast Cancer

Metastatic Breast Cancer

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Elacestrant

Alpelisib

Everolimus

Ribociclib

Palbociclib

Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS)

Recruiting

Phase 3

Sponsor:

Novartis Pharmaceuticals

Location:

Saint Louis, Phoenix, Scottsdale, Tucsonshow 60 more

Code:

NCT05147220

Conditions

Relapsing Multiple Sclerosis

Eligibility Criteria

Sex: All

Age: 18 - 55

Healthy Volunteers: Not accepted

Interventions

Remibrutinib

Teriflunomide

TACTIVE-U: A Study to Learn About the Study Medicine (Vepdegestrant) When Given With Other Medicines in People With Advanced or Metastatic Breast Cancer (Sub-Study A)

Recruiting

Phase 1

Phase 2

Sponsor:

Pfizer

Location:

Saint Peters, Saint Louis, Florissant, Creve Coeurshow 9 more

Code:

NCT05548127

Conditions

Breast Cancer

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

ARV-471

Abemaciclib

Efficacy and Safety Studies of Frexalimab (SAR441344) in Adults With Relapsing Forms of Multiple Sclerosis

Recruiting

Phase 3

Sponsor:

Sanofi

Location:

Saint Louis, Ozark, Birmingham, Cullmanshow 61 more

Code:

NCT06141473

Conditions

Multiple Sclerosis

Eligibility Criteria

Sex: All

Age: 18 - 55

Healthy Volunteers: Not accepted

Interventions

Frexalimab

Teriflunomide

Placebo infusion

Placebo tablet

MRI contrast-enhancing agents

Cabozantinib in High Grade Neuroendocrine Neoplasms

Recruiting

Phase 2

Sponsor:

Washington University School of Medicine

Location:

Saint Louis

Code:

NCT04412629

Conditions

High Grade Neuroendocrine Neoplasms

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Cabozantinib

Blood for plasma biomarkers

Tissue biopsy

IMPRoving Outcomes in Vascular DisEase- Aortic Dissection

Recruiting

Sponsor:

Duke University

Location:

Saint Louis, Phoenix, Long Beach, Los Angelesshow 29 more

Code:

NCT06087029

Conditions

Type B Aortic Dissection

Eligibility Criteria

Sex: All

Age: 21+

Healthy Volunteers: Not accepted

Interventions

TEVAR

Guideline directed medical therapy and surveillance of dissection

A Study of NVL-520 in Patients With Advanced NSCLC and Other Solid Tumors Harboring ROS1 Rearrangement (ARROS-1)

Recruiting

Phase 1

Phase 2

Sponsor:

Nuvalent Inc.

Location:

Saint Louis, Orange, Palo Alto, Sacramentoshow 13 more

Code:

NCT05118789

Conditions

Locally Advanced Solid Tumor

Metastatic Solid Tumor

Eligibility Criteria

Sex: All

Age: 12+

Healthy Volunteers: Not accepted

Interventions

NVL-520

e.g. Respiratory Diseases

St. Louis•Healthy volunteers: No

Filter results

Results: 1,432

A First-in-human Dose Escalation and Expansion Study to Evaluate the Safety, and Tolerability of AZD8421 Alone or in Combination in Participants With Selected Advanced or Metastatic Solid Tumors

Recruiting

Phase 1

Phase 2

Sponsor:

AstraZeneca

Location:

Saint Louis, Providence, Nashville, Houston

Code:

NCT06188520

Conditions

ER+ HER2- Advanced Breast Cancer

High-grade Serous Ovarian Cancer (HGSOC)

Eligibility Criteria

Sex: Female

Age: 18+

Healthy Volunteers: Not accepted

Interventions

AZD8421

Camizestrant

Ribociclib

Palbociclib

Abemaciclib

A Phase 2 Study of Firi-cel in Patients With Relapsed/Refractory Large B-cell Lymphoma

Recruiting

Phase 2

Sponsor:

CARGO Therapeutics

Location:

Saint Louis, Little Rock, Duarte, Los Angelesshow 23 more

Code:

NCT05972720

Conditions

Cancer

Relapsed/Refractory Large B-cell Lymphoma (LBCL)

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Fludarabine (Conditional therapy)

Cyclophosphamide Monohydrate (Conditional therapy)

firi-cel (Experimental drug)

A First-in-Human Study of BGB-C354 Alone and in Combination With Tislelizumab in Participants With Advanced Solid Tumors

Recruiting

Phase 1

Sponsor:

BeiGene

Location:

Saint Louis, Orlando, Houston, San Antonio

Code:

NCT06422520

Conditions

Advanced Solid Tumor

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

BGB-C354

Tislelizumab

Open-Label Umbrella Study To Evaluate Safety And Efficacy Of Elacestrant In Various Combination In Patients With Metastatic Breast Cancer

Recruiting

Phase 1

Phase 2

Sponsor:

Stemline Therapeutics, Inc.

Location:

Saint Louis, Dothan, Phoenix, Springdaleshow 37 more

Code:

NCT05563220

Conditions

Breast Cancer

Metastatic Breast Cancer

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Elacestrant

Alpelisib

Everolimus

Ribociclib

Palbociclib

Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS)

Recruiting

Phase 3

Sponsor:

Novartis Pharmaceuticals

Location:

Saint Louis, Phoenix, Scottsdale, Tucsonshow 60 more

Code:

NCT05147220

Conditions

Relapsing Multiple Sclerosis

Eligibility Criteria

Sex: All

Age: 18 - 55

Healthy Volunteers: Not accepted

Interventions

Remibrutinib

Teriflunomide

TACTIVE-U: A Study to Learn About the Study Medicine (Vepdegestrant) When Given With Other Medicines in People With Advanced or Metastatic Breast Cancer (Sub-Study A)

Recruiting

Phase 1

Phase 2

Sponsor:

Pfizer

Location:

Saint Peters, Saint Louis, Florissant, Creve Coeurshow 9 more

Code:

NCT05548127

Conditions

Breast Cancer

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

ARV-471

Abemaciclib

Efficacy and Safety Studies of Frexalimab (SAR441344) in Adults With Relapsing Forms of Multiple Sclerosis

Recruiting

Phase 3

Sponsor:

Sanofi

Location:

Saint Louis, Ozark, Birmingham, Cullmanshow 61 more

Code:

NCT06141473

Conditions

Multiple Sclerosis

Eligibility Criteria

Sex: All

Age: 18 - 55

Healthy Volunteers: Not accepted

Interventions

Frexalimab

Teriflunomide

Placebo infusion

Placebo tablet

MRI contrast-enhancing agents

Cabozantinib in High Grade Neuroendocrine Neoplasms

Recruiting

Phase 2

Sponsor:

Washington University School of Medicine

Location:

Saint Louis

Code:

NCT04412629

Conditions

High Grade Neuroendocrine Neoplasms

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Cabozantinib

Blood for plasma biomarkers

Tissue biopsy

IMPRoving Outcomes in Vascular DisEase- Aortic Dissection

Recruiting

Sponsor:

Duke University

Location:

Saint Louis, Phoenix, Long Beach, Los Angelesshow 29 more

Code:

NCT06087029

Conditions

Type B Aortic Dissection

Eligibility Criteria

Sex: All

Age: 21+

Healthy Volunteers: Not accepted

Interventions

TEVAR

Guideline directed medical therapy and surveillance of dissection

A Study of NVL-520 in Patients With Advanced NSCLC and Other Solid Tumors Harboring ROS1 Rearrangement (ARROS-1)

Recruiting

Phase 1

Phase 2

Sponsor:

Nuvalent Inc.

Location:

Saint Louis, Orange, Palo Alto, Sacramentoshow 13 more

Code:

NCT05118789

Conditions

Locally Advanced Solid Tumor

Metastatic Solid Tumor

Eligibility Criteria

Sex: All

Age: 12+

Healthy Volunteers: Not accepted

Interventions

NVL-520