A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumors That Express EGFR and Have Lost HLA-A*02 Expression
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With a vast healthcare network and top-tier medical research centers, Los Angeles is a key hub for a wide range of clinical trials. Renowned institutions such as UCLA Health, Cedars-Sinai Medical Center, and the Keck School of Medicine at USC lead pioneering research across various fields, including cancer, cardiovascular health, and neuroscience.
Many Los Angeles medical centers are at the forefront of innovative studies, positioning the city as a critical location for advancing medical research and improving patient care outcomes.
Why choose Los Angeles for clinical trials?
Los Angeles offers distinct advantages for individuals participating in clinical trials. The city’s diverse population provides a wide range of participants, enhancing the accuracy and applicability of research findings across different demographics.
Known for its forward-thinking research environment, Los Angeles is home to leading institutions that drive cutting-edge studies in a variety of medical fields. By choosing to participate in a clinical trial in Los Angeles, individuals contribute to groundbreaking medical research while benefiting from the city's well-established clinical research infrastructure and access to world-class healthcare professionals.
Common conditions studied in Los Angeles
Los Angeles is renowned for its contributions to clinical trials across a variety of medical conditions and diseases, with several institutions leading research in key areas
Neurological disorders
Los Angeles is at the forefront of research on neurological diseases like Alzheimer's, Parkinson's, and multiple sclerosis (MS). The Mary S. Easton Center for Alzheimer's Disease Research at UCLA runs clinical trials aimed at delaying the onset of neurodegenerative conditions or slowing disease progression. These trials investigate novel pharmaceuticals, including anti-amyloid therapies that target proteins believed to play a role in Alzheimer's, and cutting-edge brain stimulation techniques designed to improve cognitive function.
Trials at USC’s Keck School of Medicine also focus on therapies that could prevent or mitigate the symptoms of Parkinson’s disease and other movement disorders.
Cardiovascular disease
The Smidt Heart Institute at Cedars-Sinai is a global leader in heart disease research. It conducts pioneering clinical trials on conditions such as heart failure, arrhythmias, and hypertension. Many of these cardiovascular studies involve minimally invasive procedures and robotic surgeries that improve recovery times and patient outcomes.
Some medical centers in LA also lead research into next-generation cardiac devices, including advanced pacemakers and artificial hearts, while exploring innovative therapies like stem cell treatments to regenerate damaged heart tissue.
Diabetes and metabolic disorders
Los Angeles, with its high rates of Type 2 diabetes, plays a crucial role in diabetes research. USC’s Diabetes & Obesity Research Institute is leading trials that delve into both the prevention and treatment of diabetes. These studies investigate new medications that regulate blood sugar levels, advanced insulin delivery systems, and emerging technologies like continuous glucose monitors (CGMs), which provide real-time data for better management.
The focus on metabolic health in clinical trials also extends to obesity, where trials are looking at behavioral interventions and bariatric surgery techniques to address this growing public health issue.
Cancer
Los Angeles is internationally recognized for cancer research, particularly at UCLA’s Jonsson Comprehensive Cancer Center and Cedars-Sinai’s Samuel Oschin Cancer Center. Clinical trials here explore a range of cutting-edge treatments, including CAR-T cell therapy, which reprograms the body’s immune cells to attack cancer, and immunotherapies that boost the body's natural defenses.
These trials often target aggressive forms of cancer, including pancreatic, triple-negative breast, lung, and prostate cancers, offering patients access to the latest experimental treatments and personalized care approaches.
Interested in learning more about how clinical trials for cancer work? Explore our guide to better understand oncology clinical trials and how they contribute to advancing cancer treatmets.
Mental health conditions
LA is home to some of the most advanced clinical trials in mental health, focusing on psychiatric conditions like depression, anxiety, schizophrenia, and bipolar disorder. Los Angeles researchers are exploring innovative treatments, including psychedelic-assisted therapy with substances like psilocybin and MDMA, which are showing promise for treatment-resistant depression and PTSD.
Other trials look at new antidepressants, digital mental health therapies, and cognitive-behavioral techniques designed to improve long-term mental health outcomes.
Infectious diseases
Los Angeles has long been at the cutting edge of infectious diseases such as HIV/AIDS research, playing a major role in the development of antiretroviral therapies (ART). Institutions like UCLA and USC conduct clinical trials that are exploring long-acting injectables, antibody therapies, and even potential cures for HIV. Pre-exposure prophylaxis (PrEP) research also continues to evolve in LA, as researchers work to make it more accessible and effective.
LA has also been instrumental in clinical trials for COVID-19 vaccines and treatments, with Cedars-Sinai and other medical centers leading research on antiviral drugs, monoclonal antibodies, and long COVID treatments, making significant contributions to public health on a global scale.
Orthopedic and regenerative medicine
Some clinical trials in Los Angeles focus on advanced orthopedic treatments and regenerative medicine, particularly at Cedars-Sinai and UCLA. These trials explore treatments for joint injuries, spinal conditions, and osteoarthritis using cutting-edge therapies like stem cell injections, gene therapy, and platelet-rich plasma (PRP) treatments, which help repair and regenerate damaged tissues.
LA is also a leader in developing next-generation prosthetics, robotic-assisted surgeries, and minimally invasive techniques that aim to reduce recovery time and improve mobility for patients with chronic joint or spine issues.
Local regulations and guidelines
In Los Angeles, clinical trials must adhere to strict federal, state, and local regulations to ensure participant safety and ethical research practices. All studies are subject to the U.S. Food and Drug Administration (FDA) guidelines, which require rigorous review and approval processes, including compliance with Good Clinical Practice (GCP) standards. Each clinical trial must also receive approval from an Institutional Review Board (IRB), which is responsible for ensuring that the rights and welfare of participants are protected, that informed consent is obtained, and that the risks are minimized.
At state level, the California Department of Public Health (CDPH) oversees clinical research activities, enforcing regulations related to medical research and the protection of human subjects. In Los Angeles, institutions also have their own internal policies and ethics committees that supplement state and federal guidelines. Additionally, compliance with Health Insurance Portability and Accountability Act (HIPAA) regulations is essential for safeguarding participant health information throughout the clinical trial process.
Benefits of participating in clinical trials
Enrolling in a clinical trial offers individuals a unique opportunity to experience innovative treatments and therapies that are not yet available to the general public. Participants receive personalized care, with dedicated healthcare professionals closely monitoring their health and progress throughout the duration of the study. This level of attention ensures any potential side effects are managed effectively while also maximizing the benefits of the experimental interventions.
Participation in clinical trials is essential for fostering medical progress, often leading to significant breakthroughs in the treatment and prevention of various diseases. By joining these studies, individuals not only gain early access to potentially transformative therapies but also contribute to the broader scientific community. Clinical trial volunteers are instrumental in enhancing our understanding of medical conditions and refining future healthcare practices.
How to enroll in a clinical trial in Los Angeles
Enrolling in a clinical trial through our platform is a straightforward and user-friendly process. Here's how to get started:
- Identify your trial: Use our intuitive search bar or filter options to locate clinical trials specific to requirements. This first step simplifies the process of finding relevant research studies tailored to your needs.
- Select your preferred location: To find trials conveniently located near you, simply input your preferred location into the dedicated filter bar on the left-hand side of the page.
- Explore study details: For in-depth information about each study, simply click the “Learn More” button. This will provide you with comprehensive details about the trial, including objectives, procedures, and eligibility criteria.
- Complete the health profile: After clicking on the “Get started” button you will be taken to our efficient 5-step application process to provide important health information. This helps us match you with the clinical trial that best fits your needs.
- Submit the application: After completing the application, send it in. A clinical trial coordinator will review it and contact you regarding the possibility of participation.