Chronic Sinusitis Clinical Trials
Find clinical trials for Chronic Sinusitis. Search for Chronic Sinusitis clinical trials in different cities and states across the United States.
Nasal Potential Difference (NPD) Protocol in Chronic RhinosinusitisNasal Potential Difference (NPD) Protocol in Chronic Rhinosinusitis
Sponsor:
University of Alabama at Birmingham
Location:
Code:
NCT02038166
Conditions
Rhinosinusitis
Eligibility Criteria
Sex: All
Age: 18+
Healthy Volunteers: Not accepted
Gel-Sinuplasty for Chronic Rhinosinusitis With and Without Nasal PolyposisGel-Sinuplasty for Chronic Rhinosinusitis With and Without Nasal Polyposis
Sponsor:
LifeBridge Health
Location:
Code:
NCT03472144
Conditions
Chronic Sinusitis, Ethmoidal
Chronic Sinusitis - Ethmoidal Anterior
Chronic Sinusitis
Chronic Sinusitis - Ethmoidal, Posterior
Chronic Sinusitis, Sphenoidal
Eligibility Criteria
Sex: All
Age: 18+
Healthy Volunteers: Not accepted
Interventions
gel loaded with steroids (momentasone)
gel loaded with antibiotic (Levofloxacin)
gel loaded with both steroids and antibiotic
Ivacaftor for Acquired CFTR Dysfunction in Chronic RhinosinusitisIvacaftor for Acquired CFTR Dysfunction in Chronic Rhinosinusitis
Sponsor:
University of Alabama at Birmingham
Location:
Code:
NCT03439865
Conditions
Chronic Rhinosinusitis (Diagnosis)
Eligibility Criteria
Sex: All
Age: 18+
Healthy Volunteers: Not accepted
Interventions
Ivacaftor
standard of care treatment
Impact of Sinus Surgery on Individuals With Cystic FibrosisImpact of Sinus Surgery on Individuals With Cystic Fibrosis
Sponsor:
UCLA
Location:
Code:
NCT04469439
Conditions
Chronic Rhinosinusitis (Diagnosis)
Cystic Fibrosis
Eligibility Criteria
Sex: All
Age: 18 - 70+
Healthy Volunteers: Not accepted
Efficacy of Dupilumab for Patients With Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP)Efficacy of Dupilumab for Patients With Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP)
Sponsor:
Johns Hopkins University
Location:
Code:
NCT04362501
Conditions
Chronic Sinusitis
Eligibility Criteria
Sex: All
Age: 18 - 70+
Healthy Volunteers: Not accepted
Interventions
dupilumab
placebo
Sinus Disease in Young Children With Cystic FibrosisSinus Disease in Young Children With Cystic Fibrosis
Sponsor:
UCLA
Location:
Code:
NCT06191640
Conditions
Cystic Fibrosis in Children
Cystic Fibrosis
Chronic Rhinosinusitis (Diagnosis)
Olfactory Disorder
Olfactory Impairment
Eligibility Criteria
Sex: All
Age: 2 - 8
Healthy Volunteers: Not accepted
Interventions
Ivacaftor or elexacaftor/tezacaftor/ivacaftor
A Proof-of-concept Study of Lunsekimig Compared With Placebo in Adults With Chronic Rhinosinusitis With Nasal PolypsA Proof-of-concept Study of Lunsekimig Compared With Placebo in Adults With Chronic Rhinosinusitis With Nasal Polyps
Sponsor:
Sanofi
Location:
Code:
NCT06454240
Conditions
Chronic Rhinosinusitis With Nasal Polyps
Eligibility Criteria
Sex: All
Age: 18 - 70
Healthy Volunteers: Not accepted
Interventions
lunsekimig
placebo
A Study to Investigate Changes in Symptoms in Adult Participants With Chronic Rhinosinusitis With Nasal Polyposis Initiating Treatment With TezepelumabA Study to Investigate Changes in Symptoms in Adult Participants With Chronic Rhinosinusitis With Nasal Polyposis Initiating Treatment With Tezepelumab
Sponsor:
AstraZeneca
Location:
Code:
NCT06706817
Conditions
Chronic Rhinosinusitis With Nasal Polyps
Eligibility Criteria
Sex: All
Age: 18 - 70+
Healthy Volunteers: Not accepted
Interventions
Tezepelumab
Chronic sinusitis, also known as chronic rhinosinusitis, is a persistent inflammation of the paranasal sinuses that lasts for more than 12 weeks. This condition often leads to constant nasal congestion, facial pressure, and headaches.
There are two primary forms: chronic rhinosinusitis with nasal polyps (CRSwNP) and chronic rhinosinusitis without nasal polyps (CRSsNP). Each form presents different challenges in treatment, but clinical trials are actively investigating new therapies for both.
Chronic sinusitis symptoms and diagnosis
Common symptoms include nasal congestion, sinus congestion, and difficulty breathing through the nose. Recurrent infections or a chronic sinus infection may also occur. Severe cases often lead to a severe sinus infection that may require specialized sinusitis inflammation treatment or surgery.
Chronic sinusitis treatment options
Effective chronic sinusitis treatment depends on the underlying cause. Bacterial rhinosinusitis may require antibiotics, while other forms can benefit from nasal sprays, corticosteroids, or surgery. Patients with chronic rhinosinusitis treatment needs may also explore newer therapies, including advanced treatments for polyposis sinusitis and chronic nasal congestion treatment.
Challenges in treating chronic sinusitis
Treating chronic sinusitis can be complex, especially for patients who don't respond well to traditional treatments like corticosteroids or surgery. Many patients continue to suffer from chronic nasal congestion, recurring sinus infections, and other debilitating symptoms. Finding the right chronic sinusitis treatment is often a process of trial and error.
However, participation in clinical trials opens the door to new treatment options, from targeted biologics to innovative therapies addressing chronic sinus congestion treatment and bacterial rhinosinusitis.
Innovative treatments through clinical trials
Current clinical trials focus on advanced therapies for managing chronic sinusitis and related conditions, such as constant nasal congestion and chronic sinus infection. Trials investigating biologics, such as Dupilumab, are exploring cutting-edge treatments for patients with severe sinus infection and chronic nasal congestion who haven't responded to standard therapies.
These trials also evaluate new medications targeting sinusitis inflammation treatment, providing alternative options to traditional steroids or surgery.
Biologic trials
Biologic trials are exploring new treatment options for chronic sinusitis, particularly for patients with chronic rhinosinusitis with nasal polyps. These trials focus on biologic therapies that target specific pathways in the immune system, which play a crucial role in causing inflammation.
Unlike traditional treatments that may suppress the immune response broadly, biologics aim to directly address the underlying causes of inflammation. By doing so, they can potentially provide significant relief from symptoms such as nasal congestion, sinus pressure, and frequent infections.
Inflammation reduction studies
Inflammation reduction studies are tackling chronic inflammation in the nasal passages, a key issue for patients with both chronic rhinosinusitis without nasal polyps and chronic rhinosinusitis with nasal polyps. These trials aim to develop targeted therapies that specifically reduce inflammation at its source.
Researchers are working on innovative approaches and medications designed to relieve symptoms like nasal obstruction, facial pain, and decreased sense of smell. The ultimate goal is to improve patients' overall well-being by minimizing the chronic inflammation that can lead to debilitating symptoms and recurrent infections.
Benefits of participating in chronic sinusitis clinical trials
Participating in a clinical trial for chronic sinusitis not only gives you access to the latest treatments but also helps advance medical research.
Access to new treatments
Clinical trials offer patients the opportunity to try new therapies that may not be available through traditional healthcare providers. If you suffer from chronic sinusitis disease or chronic sinus infection, these trials may help you find an alternative when other treatments have not worked.
Personalized care
Clinical trials often provide patients with specialized attention and care, ensuring that your symptoms of nasal congestion, chronic nasal congestion, or polyposis sinusitis are closely monitored.
Contribution to medical research
By participating in trials, you contribute to the development of future therapies that could benefit others suffering from chronic sinusitis and related conditions like chronic rhinosinusitis treatment.
Interested in knowing more about the benefits of participating in a clinical trial? Read our comprehensive guide to gain insights into the potential outcomes of participating. Learn about potential benefits, risks, and safety considerations to make an informed decision about your participation in a clinical trial.
What to expect when joining a chronic sinusitis clinical trial
When joining a clinical trial for chronic sinusitis, participants can expect a clear and organized process. They will first go through a screening to see if they meet the eligibility criteria. If accepted, participants will receive information about the trial's goals, procedures, and any risks involved. Regular appointments will be scheduled to monitor symptoms, which may include tests and surveys. Throughout the trial, healthcare professionals will be available to provide support and answer questions.
Eligibility for chronic sinusitis clinical trials
If you’re suffering from chronic sinus infection, severe sinus infection, or experiencing chronic nasal congestion treatment challenges, you may qualify for one of the many clinical trials currently recruiting. Eligibility typically depends on your symptoms, previous treatments, and overall health. Trials may require that you have failed previous treatments or that your symptoms are severe enough to warrant experimental therapy.
How to enroll in clinical trials for chronic sinusitis
Enrolling in a chronic sinusitis clinical trial through our platform is a straightforward and user-friendly process. Here's how to get started:
- Identify your trial: Use our search tool or filters to find chronic sinusitis clinical trials that match your specific fertility needs or interests. This step simplifies the process of finding relevant research studies tailored to your requirements.
- Select your preferred location: To find trials conveniently located near you, simply input your preferred location into the dedicated filter bar on the left-hand side of the page.
- Explore study details: For in-depth information about each study, simply click the “Learn more” button. This will provide you with comprehensive details about the trial, including objectives, procedures, and eligibility criteria.
- Complete the health profile: After clicking on the “Get started” button you will be taken to our efficient 5-step application process to provide important health information. This helps us match you with the clinical trial that best fits your needs.
- Submit the application: After completing the application, send it in. A clinical trial coordinator will review it and contact you regarding the possibility of participation.