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Chronic Sinusitis Clinical Trials

Find clinical trials for Chronic Sinusitis. Search for Chronic Sinusitis clinical trials in different cities and states across the United States.

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A Study of the Efficacy and Safety of Brensocatib in Participants With Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP)

Recruiting
PHASE2

Sponsor:

Insmed Incorporated

Location:

Quebec, Tucson, Roseville, Uplandshow 24 more

Code:

NCT06013241

Conditions

Chronic Rhinosinusitis Without Nasal Polyps

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Interventions

Brensocatib

Placebo

Mometasone furoate nasal spray (MFNS)

Unified Airway Model

Recruiting

Sponsor:

University of British Columbia

Location:

Vancouver

Code:

NCT03937427

Conditions

Chronic Rhinosinusitis (Diagnosis)

Asthma

Eligibility Criteria

Sex: All

Age: 19+

Healthy Volunteers: Not accepted

Nasal Potential Difference (NPD) Protocol in Chronic Rhinosinusitis

Recruiting

Sponsor:

University of Alabama at Birmingham

Location:

Birmingham

Code:

NCT02038166

Conditions

Rhinosinusitis

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Mechanisms of Smell Improvement With Dupilumab.

Recruiting

Sponsor:

Medical University of South Carolina

Location:

Charleston, Charlottesville

Code:

NCT05964465

Conditions

Chronic Rhinosinusitis With Nasal Polyps

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Dupilumab

Ivacaftor for Acquired CFTR Dysfunction in Chronic Rhinosinusitis

Recruiting
EARLY_PHASE1

Sponsor:

University of Alabama at Birmingham

Location:

Birmingham

Code:

NCT03439865

Conditions

Chronic Rhinosinusitis (Diagnosis)

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Ivacaftor

standard of care treatment

Identifying Predictors Of Response To Mepolizumab In CRSwNP

Recruiting

Sponsor:

Centre hospitalier de l'Université de Montréal (CHUM)

Location:

Montreal

Code:

NCT05902325

Conditions

Chronic Rhinosinusitis With Nasal Polyps

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Mepolizumab 100 MG Injection

Endoscopic Sinus Surgery for Refractory Chronic Sinusitis

Recruiting

Sponsor:

University of Calgary

Location:

Calgary, Ottawa

Code:

NCT02506426

Conditions

Sinusitis

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Interventions

Endoscopic sinus surgery + Septoplasty

Septoplasty alone

Impact of Sinus Surgery on Individuals With Cystic Fibrosis

Recruiting

Sponsor:

UCLA

Location:

Los Angeles, Stanford, Aurora, Denvershow 5 more

Code:

NCT04469439

Conditions

Chronic Rhinosinusitis (Diagnosis)

Cystic Fibrosis

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Efficacy of Dupilumab for Patients With Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP)

Recruiting
PHASE2

Sponsor:

Johns Hopkins University

Location:

Baltimore

Code:

NCT04362501

Conditions

Chronic Sinusitis

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Interventions

dupilumab

placebo

A Proof-of-concept Study of Lunsekimig Compared With Placebo in Adults With Chronic Rhinosinusitis With Nasal Polyps

Recruiting
PHASE2

Sponsor:

Sanofi

Location:

La Jolla, Roseville, Temecula, Atlantashow 6 more

Code:

NCT06454240

Conditions

Chronic Rhinosinusitis With Nasal Polyps

Eligibility Criteria

Sex: All

Age: 18 - 70

Healthy Volunteers: Not accepted

Interventions

lunsekimig

placebo

Gel-Sinuplasty for Chronic Rhinosinusitis With and Without Nasal Polyposis

Recruiting
PHASE3

Sponsor:

LifeBridge Health

Location:

Baltimore

Code:

NCT03472144

Conditions

Chronic Sinusitis, Ethmoidal

Chronic Sinusitis - Ethmoidal Anterior

Chronic Sinusitis

Chronic Sinusitis - Ethmoidal, Posterior

Chronic Sinusitis, Sphenoidal

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

gel loaded with steroids (momentasone)

gel loaded with antibiotic (Levofloxacin)

gel loaded with both steroids and antibiotic

Chronic sinusitis, also known as chronic rhinosinusitis, is a persistent inflammation of the paranasal sinuses that lasts for more than 12 weeks. This condition often leads to constant nasal congestion, facial pressure, and headaches.

There are two primary forms: chronic rhinosinusitis with nasal polyps (CRSwNP) and chronic rhinosinusitis without nasal polyps (CRSsNP). Each form presents different challenges in treatment, but clinical trials are actively investigating new therapies for both.

Chronic sinusitis symptoms and diagnosis

Chronic sinusitis treatment options

Challenges in treating chronic sinusitis

Innovative treatments through clinical trials

Benefits of participating in chronic sinusitis clinical trials

What to expect when joining a chronic sinusitis clinical trial

How to enroll in clinical trials for chronic sinusitis